Pyrrolidine → 2-(4-[1,3']Bipyrrolidinyl-1'-yl-phenyl)-6-butoxy-3,4-dihydro-2H-isoquinolin-1-one

HRID 69457Notes

Reaction equation

HRID 69457 reaction equation
[CH2:1]([O:5][C:6]1[CH:7]=[C:8]2[C:13](=[CH:14][CH:15]=1)[C:12](=[O:16])[N:11]([C:17]1[CH:22]=[CH:21][C:20]([N:23]3[CH2:27][CH2:26][C:25](=O)[CH2:24]3)=[CH:19][CH:18]=1)[CH2:10][CH2:9]2)[CH2:2][CH2:3][CH3:4].[NH:29]1[CH2:33][CH2:32][CH2:31][CH2:30]1>>[N:29]1([CH:25]2[CH2:26][CH2:27][N:23]([C:20]3[CH:19]=[CH:18][C:17]([N:11]4[CH2:10][CH2:9][C:8]5[C:13](=[CH:14][CH:15]=[C:6]([O:5][CH2:1][CH2:2][CH2:3][CH3:4])[CH:7]=5)[C:12]4=[O:16])=[CH:22][CH:21]=3)[CH2:24]2)[CH2:33][CH2:32][CH2:31][CH2:30]1

Participants

3

Reactant 2

HCID 31268PyrrolidineHCID 68988088HCID 68988088, compound

Product 1

HCID 579169072-(4-[1,3']Bipyrrolidinyl-1'-yl-phenyl)-6-butoxy-3,4-dihydro-2H-isoquinolin-1-one

Procedure

According to Method J, 6-butoxy-2-[4-(3-oxo-pyrrolidin-1-yl)-phenyl]-3,4-dihydro-2H-isoquinolin-1-one was reacted with pyrrolidine. In this way the product was obtained with molecular weight 433.60 (C27H35N3O2); MS (ESI): 434 (M+H+).

Workup

  1. customIn this way the product was obtained with molecular weight 433.60 (C27H35N3O2)

Sources & evidence

ORD record
ord-099eea9d727c4aa4aa920a1114592417
Source dataset
uspto-grants-2014_09
Patent number
US08822495B2

Reaction notes

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