反应详情

A solution of 4-[2-methoxy-4-(6-methoxy-1-oxo-3,4-dihydro-1H-isoquinolin-2-yl)-phenyl]-[1,4]diazepane-1-carboxylic acid tert-butyl ester in 48% HBr (10 mL) was stirred for 48 h at 80° C. The mixture was neutralized with sodium hydroxide solution, extracted with dichloromethane, dried over magnesium sulfate and concentrated. In this way the product was obtained with molecular weight 367.45 (C21H25N3O3); MS (ESI): 368 (M+H+).

1. extractionextracted with dichloromethane
2. dry with materialdried over magnesium sulfate
3. concentrationconcentrated
4. customIn this way the product was obtained with molecular weight 367.45 (C21H25N3O3)