Hydrogen Bromide → 6-Hydroxy-2-[4-(4-methyl-[1,4]diazepan-1-yl)-phenyl]-3,4-dihydro-2H-isoquinolin-1-one

HRID 69477Notes

Reaction equation

HRID 69477 reaction equation
C[O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[C:9](=[O:13])[N:8]([C:14]1[CH:19]=[CH:18][C:17]([N:20]3[CH2:26][CH2:25][CH2:24][N:23]([CH3:27])[CH2:22][CH2:21]3)=[CH:16][CH:15]=1)[CH2:7][CH2:6]2.Br>>[OH:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[C:9](=[O:13])[N:8]([C:14]1[CH:15]=[CH:16][C:17]([N:20]3[CH2:26][CH2:25][CH2:24][N:23]([CH3:27])[CH2:22][CH2:21]3)=[CH:18][CH:19]=1)[CH2:7][CH2:6]2

Participants

3

Reactant 2

HCID 260Hydrogen BromideHCID 689902646-Methoxy-2-[4-(4-methyl-[1,4]diazepan-1-yl)-phenyl]-3,4-dihydro-2H-isoquinolin-1-one

Product 1

HCID 689935356-Hydroxy-2-[4-(4-methyl-[1,4]diazepan-1-yl)-phenyl]-3,4-dihydro-2H-isoquinolin-1-one

Procedure

6-Methoxy-2-[4-(4-methyl-[1,4]diazepan-1-yl)-phenyl]-3,4-dihydro-2H-isoquinolin-1-one was reacted with 48% HBr according to Method L1. In this way the product was obtained with molecular weight 351.45 (C21H25N3O2); MS (ESI): 352 (M+H+).

Workup

  1. customIn this way the product was obtained with molecular weight 351.45 (C21H25N3O2)

Sources & evidence

ORD record
ord-aea17000532c439b8400be4b4ac4b880
Source dataset
uspto-grants-2014_09
Patent number
US08822495B2

Reaction notes

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