反应详情

ST 1385 1,1-di-indol-3-yl-butane, 290 mg (1 mmol), was thoroughly mixed and blended with potassium tertbutylate (280 mg) and tetrabutylammonium bromide (20 mg). The mixture thus obtained was held under ultrasonic stirring at ambient temperature. 640 mg (5 mmol) of benzylchloride at 0° C. were then added and the ultrasonic stirring was continued for 2 hours at room temperature. At the end of this period, the reaction mixture was treated with H2O/CHCl3; the chloroform phase was separated, washed with a small amount of water, dried on Na2SO4, filtered and concentrated to dryness. The end product was isolated and purified chromatographically on silica gel, eluting with hexane:ethyl ether 95:5.351 mg of product were obtained with a 78% yield.

1. customThe mixture thus obtained
2. stirringthe ultrasonic stirring
3. customthe chloroform phase was separated
4. washwashed with a small amount of water
5. customdried on Na2SO4
6. filtrationfiltered
7. concentrationconcentrated to dryness
8. customThe end product was isolated
9. custompurified chromatographically on silica gel
10. washeluting with hexane