Azetidine → HCID 57916886, compound

HRID 69480Notes

Reaction equation

HRID 69480 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([N:14]2[CH:23]=[CH:22][C:21]3[C:16](=[CH:17][CH:18]=[C:19]([O:24][CH2:25][C@H:26]4[CH2:30][CH2:29][CH2:28][O:27]4)[CH:20]=3)[C:15]2=[O:31])[CH:5]=[CH:6][C:7]=1[N:8]1[CH2:12][CH2:11][C:10](=O)[CH2:9]1.[NH:32]1[CH2:35][CH2:34][CH2:33]1>>[N:32]1([CH:10]2[CH2:11][CH2:12][N:8]([C:7]3[CH:6]=[CH:5][C:4]([N:14]4[CH:23]=[CH:22][C:21]5[C:16](=[CH:17][CH:18]=[C:19]([O:24][CH2:25][C@H:26]6[CH2:30][CH2:29][CH2:28][O:27]6)[CH:20]=5)[C:15]4=[O:31])=[CH:3][C:2]=3[F:1])[CH2:9]2)[CH2:35][CH2:34][CH2:33]1

Participants

3

Reactant 2

HCID 10422AzetidineHCID 689920232-[3-Fluoro-4-(3-oxo-pyrrolidin-1-yl)-phenyl]-6-[(R)-1-(tetrahydrofuran-2-yl)methoxy]-2H-isoquinolin-1-one

Product 1

HCID 57916886HCID 57916886, compound

Procedure

2-[3-Fluoro-4-(3-oxo-pyrrolidin-1-yl)-phenyl]-6-[(R)-1-(tetrahydrofuran-2-yl)methoxy]-2H-isoquinolin-1-one was reacted with azetidine according to Method J1. In this way the product was obtained with molecular weight 463.23 (C27H30FN3O3); MS (ESI): 464 (M+H+).

Workup

  1. customIn this way the product was obtained with molecular weight 463.23 (C27H30FN3O3)

Sources & evidence

ORD record
ord-52adfe9780ca4fe0aef807fab6d3b882
Source dataset
uspto-grants-2014_09
Patent number
US08822495B2

Reaction notes

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