(R)-(tetrahydrofuran-2-yl)methyl methanesulfonate → HCID 68991422, compound

HRID 69481Notes

Reaction equation

HRID 69481 reaction equation
[O:1]1[C:5]2([CH2:9][CH2:8][N:7]([C:10]3[CH:15]=[CH:14][C:13]([N:16]4[CH:25]=[CH:24][C:23]5[C:18](=[CH:19][CH:20]=[C:21]([OH:26])[CH:22]=5)[C:17]4=[O:27])=[CH:12][C:11]=3[F:28])[CH2:6]2)[O:4][CH2:3][CH2:2]1.[O:29]1[CH2:33][CH2:32][CH2:31][C@@H:30]1[CH2:34]OS(C)(=O)=O>>[O:4]1[C:5]2([CH2:9][CH2:8][N:7]([C:10]3[CH:15]=[CH:14][C:13]([N:16]4[CH:25]=[CH:24][C:23]5[C:18](=[CH:19][CH:20]=[C:21]([O:26][CH2:34][C@H:30]6[CH2:31][CH2:32][CH2:33][O:29]6)[CH:22]=5)[C:17]4=[O:27])=[CH:12][C:11]=3[F:28])[CH2:6]2)[O:1][CH2:2][CH2:3]1

Participants

3

Reactant 2

HCID 18649742(R)-(tetrahydrofuran-2-yl)methyl methanesulfonateHCID 68990655HCID 68990655, compound

Product 1

HCID 68991422HCID 68991422, compound

Procedure

2-[4-(1,4-Dioxa-7-aza-spiro[4.4]non-7-yl)-3-fluorophenyl]-6-hydroxy-2H-isoquinolin-1-one was reacted with (R)-methanesulfonic acid tetrahydrofuran-2-ylmethyl ester according to Method K1. In this way the product was obtained with molecular weight 466.19 (C26H27FN2O5); MS (ESI): 467 (M+H+).

Workup

  1. customIn this way the product was obtained with molecular weight 466.19 (C26H27FN2O5)

Sources & evidence

ORD record
ord-08fa862a8dba46e7a1be861416f9d370
Source dataset
uspto-grants-2014_09
Patent number
US08822495B2

Reaction notes

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