6-[(R)-1-(Tetrahydrofuran-2-yl)methoxy]isochromen-1-one → 2-((R)-3-Acetyl-4-[1,3']bipyrrolidinyl-1'-yl-phenyl)-6-[(R)-1-(tetrahydrofuran-2-yl)methoxy]-2H-isoquinolin-1-one

HRID 69492Notes

Reaction equation

HRID 69492 reaction equation
[O:1]1[CH2:5][CH2:4][CH2:3][C@@H:2]1[CH2:6][O:7][C:8]1[CH:9]=[C:10]2[C:15](=[CH:16][CH:17]=1)[C:14](=[O:18])O[CH:12]=[CH:11]2.[NH2:19][C:20]1[CH:21]=[CH:22][C:23]([N:29]2[CH2:33][CH2:32][C@@H:31]([N:34]3[CH2:38][CH2:37][CH2:36][CH2:35]3)[CH2:30]2)=[C:24]([C:26](=[O:28])[CH3:27])[CH:25]=1>>[C:26]([C:24]1[CH:25]=[C:20]([N:19]2[CH:12]=[CH:11][C:10]3[C:15](=[CH:16][CH:17]=[C:8]([O:7][CH2:6][C@H:2]4[CH2:3][CH2:4][CH2:5][O:1]4)[CH:9]=3)[C:14]2=[O:18])[CH:21]=[CH:22][C:23]=1[N:29]1[CH2:33][CH2:32][C@@H:31]([N:34]2[CH2:35][CH2:36][CH2:37][CH2:38]2)[CH2:30]1)(=[O:28])[CH3:27]

Participants

3

Reactant 2

HCID 668789366-[(R)-1-(Tetrahydrofuran-2-yl)methoxy]isochromen-1-oneHCID 689924201-((R)-5-amino-2-[1,3']bipyrrolidinyl-1'-yl-phenyl)-ethanone

Product 1

HCID 579168452-((R)-3-Acetyl-4-[1,3']bipyrrolidinyl-1'-yl-phenyl)-6-[(R)-1-(tetrahydrofuran-2-yl)methoxy]-2H-isoquinolin-1-one

Procedure

6-[(R)-1-(Tetrahydrofuran-2-yl)methoxy]-isochromen-1-one and 1-((R)-5-amino-2-[1,3′]bipyrrolidinyl-1′-yl-phenyl)-ethanone were reacted according to Method AJ. In this way the product was obtained with molecular weight 501.63 (C30H35N3O4); MS (ESI): 502 (M+H+).

Workup

  1. customIn this way the product was obtained with molecular weight 501.63 (C30H35N3O4)

Sources & evidence

ORD record
ord-d5186c216b384281ba8587983efdd721
Source dataset
uspto-grants-2014_09
Patent number
US08822495B2

Reaction notes

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