反应详情

A solution of 1-benzyl-3-methyl-pyrrolidine-3-carboxylic acid (500 mg), triethylamine (231 mg) and diphenylphosphoryl azide (640 mg) in tert-butanol (15 mL) was stirred at 95° C. for 4 h. After adding water it was extracted with dichloromethane, dried over magnesium sulfate and concentrated. The residue was chromatographed on silica gel. In this way the product was obtained with molecular weight 290.41 (C17H26N2O2); MS (ESI): 291 (M+H+).

1. extractionwas extracted with dichloromethane
2. dry with materialdried over magnesium sulfate
3. concentrationconcentrated
4. customThe residue was chromatographed on silica gel
5. customIn this way the product was obtained with molecular weight 290.41 (C17H26N2O2)