HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 5-[(R)-1-(tetrahydrofuran-2-yl)methoxy]-indan-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 5-Hydroxy-1-indanone | HCID 233147 | — |
| Reactant | HCID 18649742 | HCID 18649742 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 5-[(R)-1-(tetrahydrofuran-2-yl)methoxy]-indan-1-one | HCID 68989306 | — |
Reaction Steps
A solution of 5-hydroxyindanone (80 mg) and methanesulfonic acid (R)-1-(tetrahydrofuran-2-yl)methyl ester (107 mg) in DMF (1 mL) was stirred at 70° C. for 16 h. After adding water it was extracted with ether, dried over magnesium sulfate and concentrated. The residue was chromatographed on silica gel. In this way the product was obtained with molecular weight 232.28 (C14H16O3); MS (ESI): 233 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08822495B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-7f3e6357e7c0499d9f9a3072dd89921e |
| Source note | uspto-grants-2014_09 |