1-Bromo-3-methoxypropane → 2-{3-Fluoro-4-[(R)-3-(3-methoxy-propylamino)-pyrrolidin-1-yl]-phenyl}-6-[(S)-1-(tetrahydro-furan-2-yl)methoxy]-3,4-dihydro-2H-isoquinolin-1-one

HRID 69508Notes

Reaction equation

HRID 69508 reaction equation
[NH2:1][C@@H:2]1[CH2:6][CH2:5][N:4]([C:7]2[CH:12]=[CH:11][C:10]([N:13]3[CH2:22][CH2:21][C:20]4[C:15](=[CH:16][CH:17]=[C:18]([O:23][CH2:24][C@@H:25]5[CH2:29][CH2:28][CH2:27][O:26]5)[CH:19]=4)[C:14]3=[O:30])=[CH:9][C:8]=2[F:31])[CH2:3]1.Br[CH2:33][CH2:34][CH2:35][O:36][CH3:37]>>[F:31][C:8]1[CH:9]=[C:10]([N:13]2[CH2:22][CH2:21][C:20]3[C:15](=[CH:16][CH:17]=[C:18]([O:23][CH2:24][C@@H:25]4[CH2:29][CH2:28][CH2:27][O:26]4)[CH:19]=3)[C:14]2=[O:30])[CH:11]=[CH:12][C:7]=1[N:4]1[CH2:5][CH2:6][C@@H:2]([NH:1][CH2:33][CH2:34][CH2:35][O:36][CH3:37])[CH2:3]1

Participants

3

Reactant 2

HCID 5245511-Bromo-3-methoxypropaneHCID 689934172-[4-((R)-3-Amino-pyrrolidin-1-yl)-3-fluoro-phenyl]-6-[(S)-1-(tetrahydro-furan-2-yl)methoxy]-3,4-dihydro-2H-isoquinolin-1-one

Product 1

HCID 579166822-{3-Fluoro-4-[(R)-3-(3-methoxy-propylamino)-pyrrolidin-1-yl]-phenyl}-6-[(S)-1-(tetrahydro-furan-2-yl)methoxy]-3,4-dihydro-2H-isoquinolin-1-one

Procedure

2-[4-((R)-3-Amino-pyrrolidin-1-yl)-3-fluoro-phenyl]-6-[(S)-1-(tetrahydro-furan-2-yl)methoxy]-3,4-dihydro-2H-isoquinolin-1-one was reacted with 1-Bromo-3-methoxypropane by method X. The product with the molecular weight of 497.62 (C28H36FN3O4) was obtained in this way; MS (ESI): 498 (M+H+).

Workup

  1. customThe product with the molecular weight of 497.62 (C28H36FN3O4) was obtained in this way

Sources & evidence

ORD record
ord-fe9cfc372a5340349bb5687d271bbbba
Source dataset
uspto-grants-2014_09
Patent number
US08822495B2

Reaction notes

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