1-Bromo-3-methoxypropane → 2-{3-Fluoro-4-[(R)-3-(3-methoxy-propylamino)-pyrrolidin-1-yl]-phenyl}-6-[(S)-1-(tetrahydro-furan-2-yl)methoxy]-3,4-dihydro-2H-isoquinolin-1-one

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	1-Bromo-3-methoxypropane	HCID 524551	—
Edukt	2-[4-((R)-3-Amino-pyrrolidin-1-yl)-3-fluoro-phenyl]-6-[(S)-1-(tetrahydro-furan-2-yl)methoxy]-3,4-dihydro-2H-isoquinolin-1-one	HCID 68993417	—
Produkt	2-{3-Fluoro-4-[(R)-3-(3-methoxy-propylamino)-pyrrolidin-1-yl]-phenyl}-6-[(S)-1-(tetrahydro-furan-2-yl)methoxy]-3,4-dihydro-2H-isoquinolin-1-one	HCID 57916682	—

Reaktionsschritte

2-[4-((R)-3-Amino-pyrrolidin-1-yl)-3-fluoro-phenyl]-6-[(S)-1-(tetrahydro-furan-2-yl)methoxy]-3,4-dihydro-2H-isoquinolin-1-one was reacted with 1-Bromo-3-methoxypropane by method X. The product with the molecular weight of 497.62 (C28H36FN3O4) was obtained in this way; MS (ESI): 498 (M+H+).

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US08822495B2
Quelldatensatz	uspto-grants-2014_09
ORD ID	ord-fe9cfc372a5340349bb5687d271bbbba
Quellennotiz	uspto-grants-2014_09