6-[(S)-1-(tetrahydrofuran-2-yl)methoxy]isochromen-1-one → 4-(2-Methoxy-4-{1-oxo-6-[(S)-1-(tetrahydro-furan-2-yl)methoxy]-1H-isoquinolin-2-yl}-phenyl)-[1,4]diazepane-1-carboxylic acid tert-butyl ester

HRID 69516노트

반응식

HRID 69516 반응식
[O:1]1[CH2:5][CH2:4][CH2:3][C@H:2]1[CH2:6][O:7][C:8]1[CH:9]=[C:10]2[C:15](=[CH:16][CH:17]=1)[C:14](=[O:18])O[CH:12]=[CH:11]2.[C:19]([O:23][C:24]([N:26]1[CH2:32][CH2:31][CH2:30][N:29]([C:33]2[CH:38]=[CH:37][C:36]([NH2:39])=[CH:35][C:34]=2[O:40][CH3:41])[CH2:28][CH2:27]1)=[O:25])([CH3:22])([CH3:21])[CH3:20]>>[C:19]([O:23][C:24]([N:26]1[CH2:32][CH2:31][CH2:30][N:29]([C:33]2[CH:38]=[CH:37][C:36]([N:39]3[CH:12]=[CH:11][C:10]4[C:15](=[CH:16][CH:17]=[C:8]([O:7][CH2:6][C@@H:2]5[CH2:3][CH2:4][CH2:5][O:1]5)[CH:9]=4)[C:14]3=[O:18])=[CH:35][C:34]=2[O:40][CH3:41])[CH2:28][CH2:27]1)=[O:25])([CH3:22])([CH3:21])[CH3:20]

참가 물질

3

반응물 2

HCID 668796906-[(S)-1-(tetrahydrofuran-2-yl)methoxy]isochromen-1-oneHCID 689879374-(4-Amino-2-methoxyphenyl)-[1,4]diazepane-1-carboxylic acid tert-butyl ester

생성물 1

HCID 689914974-(2-Methoxy-4-{1-oxo-6-[(S)-1-(tetrahydro-furan-2-yl)methoxy]-1H-isoquinolin-2-yl}-phenyl)-[1,4]diazepane-1-carboxylic acid tert-butyl ester

실험 절차

Reaction of 6-[(S)-1-(Tetrahydro-furan-2-yl)methoxy]-isochromen-1-one with 4-(4-Amino-2-methoxy-phenyl)-[1,4]diazepane-1-carboxylic acid tert-butyl ester by method AJ resulted in the desired product with the molecular weight of 549.67 (C31H39N3O6); MS (ESI): 550 (M+H+).

출처 및 근거

ORD 기록
ord-486c705217e54ff98f15dac07144bc8b
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08822495B2

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