Tetrahydro-4H-pyran-4-one → 2-{3-Methoxy-4-[4-(tetrahydro-pyran-4-yl)-[1,4]diazepan-1-yl]-phenyl}-6-[(S)-1-(tetrahydro-furan-2-yl)methoxy]-2H-isoquinolin-1-one

Participants

Role	Name	HCID	Charge
Reactant	Tetrahydro-4H-pyran-4-one	HCID 121599	—
Reactant	2-(4-[1,4]Diazepan-1-yl-3-methoxy-phenyl)-6-[(S)-1-(tetrahydro-furan-2-yl)methoxy]-2H-isoquinolin-1-one	HCID 68991377	—
Product	2-{3-Methoxy-4-[4-(tetrahydro-pyran-4-yl)-[1,4]diazepan-1-yl]-phenyl}-6-[(S)-1-(tetrahydro-furan-2-yl)methoxy]-2H-isoquinolin-1-one	HCID 68992438	—

Reaction Steps

Reaction of 2-(4-[1,4]Diazepan-1-yl-3-methoxy-phenyl)-6-[(S)-1-(tetrahydro-furan-2-yl)methoxy]-2H-isoquinolin-1-one with Tetrahydro-pyran-4-one by method J resulted in the desired product with the molecular weight 533.67 (C31H39N3O5); MS (ESI): 534 (M+H+).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08822495B2
Source dataset	uspto-grants-2014_09
ORD ID	ord-50f8bac1961344b2ae3b174095bba9b0
Source note	uspto-grants-2014_09