Tetrahydro-4H-pyran-4-one → 2-{3-Methoxy-4-[4-(tetrahydro-pyran-4-yl)-[1,4]diazepan-1-yl]-phenyl}-6-[(S)-1-(tetrahydro-furan-2-yl)methoxy]-2H-isoquinolin-1-one

HRID 69518Notes

Reaction equation

HRID 69518 reaction equation
[N:1]1([C:8]2[CH:13]=[CH:12][C:11]([N:14]3[CH:23]=[CH:22][C:21]4[C:16](=[CH:17][CH:18]=[C:19]([O:24][CH2:25][C@@H:26]5[CH2:30][CH2:29][CH2:28][O:27]5)[CH:20]=4)[C:15]3=[O:31])=[CH:10][C:9]=2[O:32][CH3:33])[CH2:7][CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.[O:34]1[CH2:39][CH2:38][C:37](=O)[CH2:36][CH2:35]1>>[CH3:33][O:32][C:9]1[CH:10]=[C:11]([N:14]2[CH:23]=[CH:22][C:21]3[C:16](=[CH:17][CH:18]=[C:19]([O:24][CH2:25][C@@H:26]4[CH2:30][CH2:29][CH2:28][O:27]4)[CH:20]=3)[C:15]2=[O:31])[CH:12]=[CH:13][C:8]=1[N:1]1[CH2:7][CH2:6][CH2:5][N:4]([CH:37]2[CH2:38][CH2:39][O:34][CH2:35][CH2:36]2)[CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 121599Tetrahydro-4H-pyran-4-oneHCID 689913772-(4-[1,4]Diazepan-1-yl-3-methoxy-phenyl)-6-[(S)-1-(tetrahydro-furan-2-yl)methoxy]-2H-isoquinolin-1-one

Product 1

HCID 689924382-{3-Methoxy-4-[4-(tetrahydro-pyran-4-yl)-[1,4]diazepan-1-yl]-phenyl}-6-[(S)-1-(tetrahydro-furan-2-yl)methoxy]-2H-isoquinolin-1-one

Procedure

Reaction of 2-(4-[1,4]Diazepan-1-yl-3-methoxy-phenyl)-6-[(S)-1-(tetrahydro-furan-2-yl)methoxy]-2H-isoquinolin-1-one with Tetrahydro-pyran-4-one by method J resulted in the desired product with the molecular weight 533.67 (C31H39N3O5); MS (ESI): 534 (M+H+).

Sources & evidence

ORD record
ord-50f8bac1961344b2ae3b174095bba9b0
Source dataset
uspto-grants-2014_09
Patent number
US08822495B2

Reaction notes

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