1,2-Difluoro-4-nitrobenzene → HCID 68992896, compound

HRID 69522Notes

Reaction equation

HRID 69522 reaction equation
F[C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-])=O)=[CH:4][C:3]=1[F:11].[C:12]([O:16][C:17]([N:19]1[CH2:22][C:21]2([CH2:26][CH2:25][NH:24][CH2:23]2)[CH2:20]1)=[O:18])([CH3:15])([CH3:14])[CH3:13]>>[C:12]([O:16][C:17]([N:19]1[CH2:22][C:21]2([CH2:26][CH2:25][N:24]([C:2]3[CH:7]=[CH:6][C:5]([NH2:8])=[CH:4][C:3]=3[F:11])[CH2:23]2)[CH2:20]1)=[O:18])([CH3:15])([CH3:13])[CH3:14]

Participants

3

Reactant 2

HCID 1230531,2-Difluoro-4-nitrobenzeneHCID 49757941Tert-butyl 2,6-diazaspiro[3.4]octane-2-carboxylate

Product 1

HCID 68992896HCID 68992896, compound

Procedure

According to methods E and F, 1,2-Difluoro-4-nitro-benzene was reacted with 2,6-Diaza-spiro[3.4]octane-2-carboxylic acid tert-butyl ester and hydrogenated. The product with the molecular weight of 321, 40 (C17H24FN3O2) was obtained in this way; MS (ESI): 322 (M+H+).

Workup

  1. customThe product with the molecular weight of 321, 40 (C17H24FN3O2) was obtained in this way

Sources & evidence

ORD record
ord-662bcf1fb3a94ce68eb275bfad8b7632
Source dataset
uspto-grants-2014_09
Patent number
US08822495B2

Reaction notes

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