反应详情

温度

100 °C

2-Benzenesulfonyl-7-[2-(tert-butoxycarbonyl-methyl-amino)-ethoxy]-indole-1-carboxylic acid tert-butyl ester (0.230 g., 0.43 mmol) from the above step was dissolved in 5 mL EtOH. To this solution was added 1 mL of 2M ethanolic hydrogen chloride solution. The reaction mixture was heated at 100° C. for 35 minutes. Upon cooling to ambient temperature, a fine white precipitate was observed. After filtration and drying in vacuo at 60° C., [2-(2-Benzenesulfonyl-1H-indol-7-yloxy)-ethyl]-methyl-amine hydrochloride was obtained as 0.140 g. white crystals. MS: 329 (M−H)−, mp=289.4–291.6° C.

1. temperatureUpon cooling to ambient temperature
2. filtrationAfter filtration
3. customdrying in vacuo at 60° C.