Dichloromethane → N-[3-(2-amino-4,4a,5,6-tetrahydrofuro[2,3-d][1,3]thiazin-7a-yl)-4-fluorophenyl]-5-fluoropyridine-2-carboxamide

HRID 695605Notes

Reaction equation

HRID 695605 reaction equation
[Cl:42][CH2:43][Cl:44].[F:1][c:2]1[c:3]([C:18]23[N:19]=[C:20]([NH:27][C:28](=[O:29])[O:30][C:31]([CH3:32])([CH3:33])[CH3:34])[S:21][CH2:22][CH:23]2[CH2:24][CH2:25][O:26]3)[cH:4][c:5]([NH:8][C:9]([c:10]2[n:11][cH:12][c:13]([F:16])[cH:14][cH:15]2)=[O:17])[cH:6][cH:7]1.[F:35][C:36]([F:37])([F:38])[C:39]([OH:40])=[O:41]>>[F:1][c:2]1[c:3]([C:18]23[N:19]=[C:20]([NH2:27])[S:21][CH2:22][CH:23]2[CH2:24][CH2:25][O:26]3)[cH:4][c:5]([NH:8][C:9]([c:10]2[n:11][cH:12][c:13]([F:16])[cH:14][cH:15]2)=[O:17])[cH:6][cH:7]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 123155127tert-butyl N-[7a-[2-fluoro-5-[(5-fluoropyridine-2-carbonyl)amino]phenyl]-4,4a,5,6-tetrahydrofuro[2,3-d][1,3]thiazin-2-yl]carbamate

Product 1

HCID 123861199N-[3-(2-amino-4,4a,5,6-tetrahydrofuro[2,3-d][1,3]thiazin-7a-yl)-4-fluorophenyl]-5-fluoropyridine-2-carboxamide

Sources & evidence

ORD record
ord-abc75d97c64a4cc099e64a3214dec647
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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