2-(Bromomethyl)tetrahydro-2H-pyran → 5-fluoro-6-methoxy-1'-(oxolan-2-ylmethyl)spiro[2H-1-benzofuran-3,3'-indole]-2'-one

HRID 695646Notes

Reaction equation

HRID 695646 reaction equation
[Br:39][CH2:40][CH:41]1[CH2:42][CH2:43][CH2:44][CH2:45][O:46]1.[CH3:22][c:23]1[cH:24][cH:25][c:26]([S:27]([O:28][CH2:33][CH:34]2[O:35][CH2:36][CH2:37][CH2:38]2)(=[O:29])=[O:30])[cH:31][cH:32]1.[F:1][c:2]1[c:3]([O:20][CH3:21])[cH:4][c:5]2[c:6]([cH:19]1)[C:7]1([CH2:8][O:9]2)[C:10](=[O:18])[NH:11][c:12]2[cH:13][cH:14][cH:15][cH:16][c:17]21>>[F:1][c:2]1[c:3]([O:20][CH3:21])[cH:4][c:5]2[c:6]([cH:19]1)[C:7]1([CH2:8][O:9]2)[C:10](=[O:18])[N:11]([CH2:33][CH:34]2[O:35][CH2:36][CH2:37][CH2:38]2)[c:12]2[cH:13][cH:14][cH:15][cH:16][c:17]21

Participants

4

Reactant 3

HCID 1419172-(Bromomethyl)tetrahydro-2H-pyranHCID 4522871(Tetrahydrofuran-2-yl)methyl 4-methylbenzenesulfonateHCID 461940485-fluoro-6-methoxyspiro[1-benzofuran-3,3'-indol]-2'(1'H)-one

Product 1

HCID 722685825-fluoro-6-methoxy-1'-(oxolan-2-ylmethyl)spiro[2H-1-benzofuran-3,3'-indole]-2'-one

Sources & evidence

ORD record
ord-a043aad6ba934e8daa4acde5cda027ac
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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