Bromide ion → 3-({[Tert-butyl(dimethyl)silyl]oxy}methyl)-2-chloro-6-(2,6-difluorobenzyl)pyridine
Reaction equation
[Br-:18].[C:1]([CH3:2])([CH3:3])([CH3:4])[Si:5]([O:6][CH2:7][c:8]1[c:9]([Cl:15])[n:10][c:11]([Cl:14])[cH:12][cH:13]1)([CH3:16])[CH3:17].[CH2:29]1[O:30][CH2:31][CH2:32][CH2:33]1.[F:19][c:20]1[c:21]([CH2:22][Zn+:23])[c:24]([F:28])[cH:25][cH:26][cH:27]1.[cH:34]1[cH:35][cH:36][c:37]([P:38]([Pd:39]([P:40]([c:41]2[cH:42][cH:43][cH:44][cH:45][cH:46]2)([c:47]2[cH:48][cH:49][cH:50][cH:51][cH:52]2)[c:53]2[cH:54][cH:55][cH:56][cH:57][cH:58]2)([P:59]([c:60]2[cH:61][cH:62][cH:63][cH:64][cH:65]2)([c:66]2[cH:67][cH:68][cH:69][cH:70][cH:71]2)[c:72]2[cH:73][cH:74][cH:75][cH:76][cH:77]2)[P:78]([c:79]2[cH:80][cH:81][cH:82][cH:83][cH:84]2)([c:85]2[cH:86][cH:87][cH:88][cH:89][cH:90]2)[c:91]2[cH:92][cH:93][cH:94][cH:95][cH:96]2)([c:97]2[cH:98][cH:99][cH:100][cH:101][cH:102]2)[c:103]2[cH:104][cH:105][cH:106][cH:107][cH:108]2)[cH:109][cH:110]1>>[C:1]([CH3:2])([CH3:3])([CH3:4])[Si:5]([O:6][CH2:7][c:8]1[c:9]([Cl:15])[n:10][c:11]([CH2:22][c:21]2[c:20]([F:19])[cH:27][cH:26][cH:25][c:24]2[F:28])[cH:12][cH:13]1)([CH3:16])[CH3:17]Participants
6
Reactant 5
Product 1
Sources & evidence
- ORD record
- ord-6e752b84683643fca15672ea2099ef18
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (3/10)
Reaction notes
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