Hydrochloric Acid → 1'-[(5-chloro-1-methyl-1H-imidazol-2-yl)methyl]-2,3-dihydrospiro[furo[2,3-g][1,4]benzodioxine-8,3'-indol]-2'(1'H)-one

HRID 696232Notes

Reaction equation

HRID 696232 reaction equation
[Br:54][CH2:55][CH:56]1[CH2:57][CH2:58][CH2:59][CH2:60][O:61]1.[Cl:45][c:46]1[cH:47][n:48][c:49]([CH2:52][Cl:53])[n:50]1[CH3:51].[ClH:44].[NH:1]1[C:2](=[O:22])[C:3]2([CH2:4][O:5][c:6]3[cH:7][c:8]4[c:9]([cH:14][c:15]32)[O:10][CH2:11][CH2:12][O:13]4)[c:16]2[cH:17][cH:18][cH:19][cH:20][c:21]21.[NH:23]1[c:24]2[c:25]([cH:26][cH:27][cH:28][cH:29]2)[C:30]2([CH2:31][O:32][c:33]3[cH:34][c:35]4[c:36]([cH:37][c:38]32)[CH2:39][CH2:40][O:41]4)[C:42]1=[O:43]>>[N:1]1([CH2:52][c:49]2[n:48][cH:47][c:46]([Cl:45])[n:50]2[CH3:51])[C:2](=[O:22])[C:3]2([CH2:4][O:5][c:6]3[cH:7][c:8]4[c:9]([cH:14][c:15]32)[O:10][CH2:11][CH2:12][O:13]4)[c:16]2[cH:17][cH:18][cH:19][cH:20][c:21]21

Participants

6

Reactant 5

HCID 313Hydrochloric AcidHCID 1419172-(Bromomethyl)tetrahydro-2H-pyranHCID 49623925-chloro-2-(chloromethyl)-1-methyl-1H-imidazoleHCID 58224164Spiro[furo[2,3-g]-1,4-benzodioxin-8(7H),3'-[3H]indol]-2'(1'H)-one, 2,3-dihydroHCID 592633545,6-dihydro-2H-spiro[benzofuro[6,5-b]furan-3,3'-indolin]-2'-one

Product 1

HCID 673578011'-[(5-chloro-1-methyl-1H-imidazol-2-yl)methyl]-2,3-dihydrospiro[furo[2,3-g][1,4]benzodioxine-8,3'-indol]-2'(1'H)-one

Sources & evidence

ORD record
ord-ea839e23dd7b4feead1003c0b12716d1
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

Loading…