反应详情

温度

90 °C

To a suspension of (S)-3-(hydroxymethyl)-7,8,9,10-tetrahydro-5H-dipyrido[1,2-a:3′,2′-e]pyrazin-6(6aH)-one (800 mg, 3.43 mmol) was added (cyanomethyl)trimethylphosphonium iodide (1000 mg, 4.12 mmol) and DIEA (1797 μl, 10.29 mmol) and N-ethyl-4-(piperazin-1-yl)benzamide (800 mg, 3.43 mmol)). The vial was heated to 90° C. for 16 hours. The crude reaction was cooled to RT and filtered. The resulting solid were collected and suspended in EtOH (24 mL), heated to reflux, then cooled to RT and filtered. The resulting material was rinsed with EtOH to give a white solid.

1. customThe crude reaction
2. temperaturewas cooled to RT
3. filtrationfiltered
4. customThe resulting solid were collected
5. temperatureheated
6. temperatureto reflux
7. temperaturecooled to RT
8. filtrationfiltered
9. washThe resulting material was rinsed with EtOH
10. customto give a white solid