Hydrochloric Acid → 5-Bromo-1-methyl-3-(1,2,3,4-tetrahydroisoquinolin-6-ylamino)pyrazin-2(1H)-one

HRID 696694Notes

Reaction equation

HRID 696694 reaction equation
[Br:1][c:2]1[cH:3][n:4]([CH3:27])[c:5](=[O:26])[c:6]([NH:8][c:9]2[cH:10][c:11]3[c:16]([cH:17][cH:18]2)[CH2:15][N:14]([C:19]([O:20][C:21]([CH3:22])([CH3:23])[CH3:24])=[O:25])[CH2:13][CH2:12]3)[n:7]1.[ClH:28].[O:29]1[CH2:30][CH2:31][O:32][CH2:33][CH2:34]1>>[Br:1][c:2]1[cH:3][n:4]([CH3:27])[c:5](=[O:26])[c:6]([NH:8][c:9]2[cH:10][c:11]3[c:16]([cH:17][cH:18]2)[CH2:15][NH:14][CH2:13][CH2:12]3)[n:7]1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 58044031tert-Butyl 6-(6-bromo-4-methyl-3-oxo-3,4-dihydropyrazin-2-ylamino)-3,4-dihydroisoquinoline-2(1H)-carboxylate

Product 1

HCID 580437085-Bromo-1-methyl-3-(1,2,3,4-tetrahydroisoquinolin-6-ylamino)pyrazin-2(1H)-one

Sources & evidence

ORD record
ord-de561da1766b4ffeaac511709939697f
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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