Acetate → 2-Chloro-2'-fluoro-3,4'-bipyridine

HRID 696847Notes

Reaction equation

HRID 696847 reaction equation
[C:19](=[O:20])([O-:21])[O-:22].[CH3:31][CH2:32][O:33][C:34]([CH3:35])=[O:36].[Cl:9][c:10]1[n:11][cH:12][cH:13][cH:14][c:15]1[B:16]([OH:17])[OH:18].[F:1][c:2]1[n:3][cH:4][cH:5][c:6]([I:8])[cH:7]1.[Na+:23].[Na+:24].[O-:38][C:39]([CH3:40])=[O:41].[O-:42][C:43]([CH3:44])=[O:45].[O:25]1[CH2:26][CH2:27][O:28][CH2:29][CH2:30]1.[OH2:46].[Pd+2:37]>>[F:1][c:2]1[n:3][cH:4][cH:5][c:6](-[c:15]2[c:10]([Cl:9])[n:11][cH:12][cH:13][cH:14]2)[cH:7]1

Participants

10

Reactant 9

HCID 175Acetate2×HCID 923Sodium ion2×HCID 962WaterHCID 8857Ethyl AcetateHCID 19660Carbonate IonHCID 312751,4-DioxaneHCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 2762704(2-Chloropyridin-3-yl)boronic acidHCID 70235702-Fluoro-4-iodopyridine

Product 1

HCID 161089822-Chloro-2'-fluoro-3,4'-bipyridine

Sources & evidence

ORD record
ord-c3e5d25b433f4a619f87772c452856c6
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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