Ammonia → 3',3'-dimethyl-8'-(pyrrolidin-1-ylsulfonyl)-3',4'-dihydro-2'H-spiro[1,3-dioxane-2,10'-pyrimido[1,2-a]indole]

HRID 697082Notes

Reaction equation

HRID 697082 reaction equation
[CH2:36]1[O:37][CH2:38][CH2:39][CH2:40]1.[CH3:1][C:2]([C:3]#[N:4])([CH2:5][N:6]1[C:7](=[O:28])[C:8]2([O:9][CH2:10][CH2:11][CH2:12][O:13]2)[c:14]2[cH:15][c:16]([S:20](=[O:21])(=[O:22])[N:23]3[CH2:24][CH2:25][CH2:26][CH2:27]3)[cH:17][cH:18][c:19]21)[CH3:29].[CH3:32][CH2:33][OH:34].[H:30][H:31].[NH3:35]>>[CH3:1][C:2]1([CH3:29])[CH2:3][N:4]=[C:7]2[N:6]([CH2:5]1)[c:19]1[c:14]([cH:15][c:16]([S:20](=[O:21])(=[O:22])[N:23]3[CH2:24][CH2:25][CH2:26][CH2:27]3)[cH:17][cH:18]1)[C:8]21[O:9][CH2:10][CH2:11][CH2:12][O:13]1

Participants

6

Reactant 5

HCID 222AmmoniaHCID 702EthanolHCID 8028TetrahydrofuranHCID 589325752,2-dimethyl-3-[2'-oxo-5'-(pyrrolidin-1-ylsulfonyl)spiro[1,3-dioxane-2,3'-indol]-1'(2'H)-yl]propanenitrileHCID 178418361HCID 178418361, compound

Product 1

HCID 116614033',3'-dimethyl-8'-(pyrrolidin-1-ylsulfonyl)-3',4'-dihydro-2'H-spiro[1,3-dioxane-2,10'-pyrimido[1,2-a]indole]

Sources & evidence

ORD record
ord-26ffc3ed21e74ffe8cee50b81efeb753
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

Loading…