Dichloromethane → 8'-fluoro-5'-hydroxy-1'H-spiro[cyclohexane-1,4'-quinazolin]-2'(3'H)-one

HRID 697275Notes

Reaction equation

HRID 697275 reaction equation
[B:20]([Br:21])([Br:22])[Br:23].[C:27]([O:28][CH3:29])([CH3:30])([CH3:31])[CH3:32].[Cl:24][CH2:25][Cl:26].[F:1][c:2]1[cH:3][cH:4][c:5]([O:18][CH3:19])[c:6]2[c:7]1[NH:8][C:9](=[O:17])[NH:10][C:11]21[CH2:12][CH2:13][CH2:14][CH2:15][CH2:16]1>>[F:1][c:2]1[cH:3][cH:4][c:5]([OH:18])[c:6]2[c:7]1[NH:8][C:9](=[O:17])[NH:10][C:11]21[CH2:12][CH2:13][CH2:14][CH2:15][CH2:16]1

Participants

5

Reactant 4

HCID 6344DichloromethaneHCID 15413tert-Butyl methyl etherHCID 25134Boron tribromideHCID 693174648'-fluoro-5'-methoxy-1'H-spiro[cyclohexane-1,4'-quinazolin]-2'(3'H)-one

Product 1

HCID 534858818'-fluoro-5'-hydroxy-1'H-spiro[cyclohexane-1,4'-quinazolin]-2'(3'H)-one

Sources & evidence

ORD record
ord-009223a653af493e8f094395a84d954c
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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