Dimethylacetamide → 4-(4-Cyclopropanesulfonyl-2,3-difluoro-phenyl)-piperazine-1-carboxylic acid tert-butyl ester

HRID 697776Notes

Reaction equation

HRID 697776 reaction equation
[C:16]([CH3:17])([CH3:18])([CH3:19])[O:20][C:21](=[O:22])[N:23]1[CH2:24][CH2:25][NH:26][CH2:27][CH2:28]1.[CH3:29][N:30]([CH3:31])[C:32](=[O:33])[CH3:34].[CH:1]1([S:4](=[O:5])(=[O:6])[c:7]2[c:8]([F:15])[c:9]([F:14])[c:10]([F:13])[cH:11][cH:12]2)[CH2:2][CH2:3]1>>[CH:1]1([S:4](=[O:5])(=[O:6])[c:7]2[c:8]([F:15])[c:9]([F:14])[c:10]([N:26]3[CH2:25][CH2:24][N:23]([C:21]([O:20][C:16]([CH3:17])([CH3:18])[CH3:19])=[O:22])[CH2:28][CH2:27]3)[cH:11][cH:12]2)[CH2:2][CH2:3]1

Participants

4

Reactant 3

HCID 31374DimethylacetamideHCID 143452tert-Butyl piperazine-1-carboxylateHCID 690384121-Cyclopropanesulfonyl-2,3,4-trifluoro-benzene

Product 1

HCID 690375784-(4-Cyclopropanesulfonyl-2,3-difluoro-phenyl)-piperazine-1-carboxylic acid tert-butyl ester

Sources & evidence

ORD record
ord-1d9c7085bbd1444d9d83a7f48f414c0a
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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