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HRID69833

反应详情

EQUATION

反应方程式

HRID 69833 的结构方程式

REACTANTS

反应物

2
结构：O=[N+]([O-])c1ccccc1F
HCID73895

Benzene, 1-fluoro-2-nitro-

C6H4FNO2

结构：CC(C)(C)OC(=O)NC1CCNCC1
HCID723833

4-(N-Boc-amino)piperidine

C10H20N2O2

PRODUCTS

生成物

1
结构：CC(C)(C)OC(=O)NC1CCN(c2ccccc2[N+](=O)[O-])CC1
HCID53255688

tert-Butyl [1-(2-nitrophenyl)piperidin-4-yl]carbamate

C16H23N3O4

收率 100%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CCO
溶剂HCID702

Ethanol

C2H6O

PROCEDURE

实验过程

The method of Example 1 was followed using 1-fluoro-2-nitrobenzene (1.0 eq), 4-N-Boc-aminopiperidine (1.2 eq), and TEA (2.0 eq) in EtOH at 55° C. for 48 hours yielding tert-butyl 1-(2-nitro phenyl)piperidin-4-ylcarbamate (100%). LCMS (m/z): 322.2 (MH+); LC Rt=3.15 min.

WORKUP

后处理

  1. customat 55° C.
  2. customfor 48 hours