HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Fluoro-2-nitrobenzene → tert-Butyl (1-(2-nitrophenyl)piperidin-4-yl)carbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Fluoro-2-nitrobenzene | HCID 73895 | — |
| Reactant | 4-(N-Boc-amino)piperidine | HCID 723833 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | tert-Butyl (1-(2-nitrophenyl)piperidin-4-yl)carbamate | HCID 53255688 | 100% |
Reaction Steps
The method of Example 1 was followed using 1-fluoro-2-nitrobenzene (1.0 eq), 4-N-Boc-aminopiperidine (1.2 eq), and TEA (2.0 eq) in EtOH at 55° C. for 48 hours yielding tert-butyl 1-(2-nitro phenyl)piperidin-4-ylcarbamate (100%). LCMS (m/z): 322.2 (MH+); LC Rt=3.15 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08822497B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-19c6d757750c4c0cae9e914b2216f12e |
| Source note | uspto-grants-2014_09 |