Dichloromethane → (1,1-Dioxo-1lambda6-thiomorpholin-4-yl)-[1-isopropyl-5-(piperidin-4-yloxy)-1H-indol-2-yl]-methanone

HRID 698339Notes

Reaction equation

HRID 698339 reaction equation
[C:1]([O:2][C:3](=[O:4])[N:8]1[CH2:9][CH2:10][CH:11]([O:14][c:15]2[cH:16][c:17]3[cH:18][c:19]([C:27](=[O:28])[N:29]4[CH2:30][CH2:31][S:32](=[O:35])(=[O:36])[CH2:33][CH2:34]4)[n:20]([CH:24]([CH3:25])[CH3:26])[c:21]3[cH:22][cH:23]2)[CH2:12][CH2:13]1)([CH3:5])([CH3:6])[CH3:7].[Cl:44][CH2:45][Cl:46].[OH:37][C:38]([C:39]([F:40])([F:41])[F:42])=[O:43]>>[NH:8]1[CH2:9][CH2:10][CH:11]([O:14][c:15]2[cH:16][c:17]3[cH:18][c:19]([C:27](=[O:28])[N:29]4[CH2:30][CH2:31][S:32](=[O:35])(=[O:36])[CH2:33][CH2:34]4)[n:20]([CH:24]([CH3:25])[CH3:26])[c:21]3[cH:22][cH:23]2)[CH2:12][CH2:13]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 670734974-[2-(1,1-Dioxo-1lambda6-thiomorpholine-4-carbonyl)-1-isopropyl-1H-indol-5-yloxy]-piperidine-1-carboxylic acid tert-butyl ester

Product 1

HCID 67073486(1,1-Dioxo-1lambda6-thiomorpholin-4-yl)-[1-isopropyl-5-(piperidin-4-yloxy)-1H-indol-2-yl]-methanone

Sources & evidence

ORD record
ord-27bf4e798b6242eba453cfb5994a734b
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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