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HRID69834

反应详情

EQUATION

反应方程式

HRID 69834 的结构方程式

REACTANTS

反应物

2
结构：O=[N+]([O-])c1ccccc1F
HCID73895

Benzene, 1-fluoro-2-nitro-

C6H4FNO2

结构：CC(C)(C)OC(=O)N1CCNCC1
HCID143452

tert-Butyl piperazine-1-carboxylate

C9H18N2O2

PRODUCTS

生成物

1
结构：CC(C)(C)OC(=O)N1CCN(c2ccccc2[N+](=O)[O-])CC1
HCID21935210

tert-Butyl 4-(2-nitrophenyl)piperazine-1-carboxylate

C15H21N3O4

收率 100%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CCO
溶剂HCID702

Ethanol

C2H6O

PROCEDURE

实验过程

The method of Example 1 was followed using 1-fluoro-2-nitrobenzene (1.0 eq), 1-Boc-piperazine (1.2 eq), and TEA (2.0 eq) in EtOH at 55° C. for 72 hours yielding tert-butyl 4-(2-nitro phenyl)piperazine-1-carboxylate (100%). LCMS (m/z): 308.1 (MH+); LC Rt=3.25 min.

WORKUP

后处理

  1. customat 55° C.
  2. customfor 72 hours