HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Fluoro-2-nitrobenzene → 1-Boc-4-(2-nitrophenyl)piperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Fluoro-2-nitrobenzene | HCID 73895 | — |
| Reactant | tert-Butyl piperazine-1-carboxylate | HCID 143452 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 1-Boc-4-(2-nitrophenyl)piperazine | HCID 21935210 | 100% |
Reaction Steps
The method of Example 1 was followed using 1-fluoro-2-nitrobenzene (1.0 eq), 1-Boc-piperazine (1.2 eq), and TEA (2.0 eq) in EtOH at 55° C. for 72 hours yielding tert-butyl 4-(2-nitro phenyl)piperazine-1-carboxylate (100%). LCMS (m/z): 308.1 (MH+); LC Rt=3.25 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08822497B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-ca4e9a2d63954b809a835994db004818 |
| Source note | uspto-grants-2014_09 |