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HRID69838

反应详情

EQUATION

反应方程式

HRID 69838 的结构方程式

REACTANTS

反应物

2
结构：O=[N+]([O-])c1c(F)cccc1F
HCID87922

1,3-Difluoro-2-nitrobenzene

C6H3F2NO2

结构：CC(C)(C)OC(=O)NC1CCNCC1
HCID723833

4-(N-Boc-amino)piperidine

C10H20N2O2

PRODUCTS

生成物

1
结构：CC(C)(C)OC(=O)NC1CCN(c2cccc(F)c2[N+](=O)[O-])CC1
HCID53255566

未命名化合物

收率 93%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CCO
溶剂HCID702

Ethanol

C2H6O

PROCEDURE

实验过程

Method 1 was followed using 1 eq each of 2,6-difluoronitrobenzene, 4-(N-Boc-amino) piperidine, and TEA in EtOH yielding tert-butyl 1-(3-fluoro-2-nitrophenyl)piperidin-4-ylcarbamate (93%). LCMS (m/z): 340.1 (MH+); LC Rt=3.30 min.