Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 69838Generated: October 26, 2026

1,3-Difluoro-2-nitrobenzene → tert-Butyl 1-(3-fluoro-2-nitrophenyl)piperidine-4-ylcarbamate

https://huagongshe.com/reaction/69838

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1,3-Difluoro-2-nitrobenzeneHCID 87922—
Reactant4-(N-Boc-amino)piperidineHCID 723833—
SolventEthanolHCID 702—
Producttert-Butyl 1-(3-fluoro-2-nitrophenyl)piperidine-4-ylcarbamateHCID 5325556693%

Reaction Steps

Method 1 was followed using 1 eq each of 2,6-difluoronitrobenzene, 4-(N-Boc-amino) piperidine, and TEA in EtOH yielding tert-butyl 1-(3-fluoro-2-nitrophenyl)piperidin-4-ylcarbamate (93%). LCMS (m/z): 340.1 (MH+); LC Rt=3.30 min.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08822497B2
Source datasetuspto-grants-2014_09
ORD IDord-59927f3e78434f798cfb8d58841466f5
Source noteuspto-grants-2014_09