HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chloro-3-nitrobenzophenone → Tert-butyl 1-(4-benzoyl-2-nitro phenyl)piperidin-4-ylcarbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chloro-3-nitrobenzophenone | HCID 41743 | — |
| Reactant | 4-(N-Boc-amino)piperidine | HCID 723833 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | Tert-butyl 1-(4-benzoyl-2-nitro phenyl)piperidin-4-ylcarbamate | HCID 60507461 | 95% |
Reaction Steps
Method 1 was followed using 4-chloro-3-nitrobenzophenone (1.0 eq), 4-(N-Boc-amino) piperidine (1.1 eq), and TEA (2.0 eq) in NMP yielding tert-butyl 1-(4-benzoyl-2-nitro phenyl)piperidin-4-ylcarbamate (95%). LCMS (m/z): 426.2 (MH+); LC Rt=3.46 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08822497B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-b382a4b1ab324815b06a0b26f8b5ee2d |
| Source note | uspto-grants-2014_09 |