HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chloro-3-nitroanisole → Tert-butyl 4-(4-methoxy-2-nitro phenyl)piperazine-1-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chloro-3-nitroanisole | HCID 25140 | — |
| Reactant | tert-Butyl piperazine-1-carboxylate | HCID 143452 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | Tert-butyl 4-(4-methoxy-2-nitro phenyl)piperazine-1-carboxylate | HCID 69043384 | 50% |
Reaction Steps
Method 1 was followed using 4-chloro-3-nitroanisole (1.0 eq), 1-Boc-piperazine (1.2 eq), and TEA (2.0 eq) in NMP at 100° C. for 16 hours yielding tert-butyl 4-(4-methoxy-2-nitro phenyl)piperazine-1-carboxylate (50%). LCMS (m/z): 338.2 (MH+); LC Rt=3.37 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08822497B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-7e48c55b25b54539b5ea005c80ce382d |
| Source note | uspto-grants-2014_09 |