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HRID69847

反应详情

EQUATION

反应方程式

HRID 69847 的结构方程式

REACTANTS

反应物

2
结构：COc1ccc(Cl)c([N+](=O)[O-])c1
HCID25140

Anisole, 4-chloro-3-nitro-

C7H6ClNO3

结构：CC(C)(C)OC(=O)N1CCNCC1
HCID143452

tert-Butyl piperazine-1-carboxylate

C9H18N2O2

PRODUCTS

生成物

1
结构：COc1ccc(N2CCN(C(=O)OC(C)(C)C)CC2)c([N+](=O)[O-])c1
HCID69043384

未命名化合物

收率 50%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CN1CCCC1=O
溶剂HCID13387

N-Methyl-2-pyrrolidone

C5H9NO

PROCEDURE

实验过程

Method 1 was followed using 4-chloro-3-nitroanisole (1.0 eq), 1-Boc-piperazine (1.2 eq), and TEA (2.0 eq) in NMP at 100° C. for 16 hours yielding tert-butyl 4-(4-methoxy-2-nitro phenyl)piperazine-1-carboxylate (50%). LCMS (m/z): 338.2 (MH+); LC Rt=3.37 min.

WORKUP

后处理

  1. customat 100° C.
  2. customfor 16 hours