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HRID69863

反应详情

EQUATION

反应方程式

HRID 69863 的结构方程式

REACTANTS

反应物

2
结构：O=C(c1ccc(Cl)c([N+](=O)[O-])c1)C1CC1
HCID1268259

4-Chloro-3-nitrophenyl cyclopropyl ketone

C10H8ClNO3

结构：CC(C)(C)OC(=O)NC1CCCNC1
HCID4233041

3-Boc-aminopiperidine

C10H20N2O2

PRODUCTS

生成物

1
结构：CC(C)(C)OC(=O)NC1CCCN(c2ccc(C(=O)C3CC3)cc2[N+](=O)[O-])C1
HCID69043896

未命名化合物

收率 96%

PROCEDURE

实验过程

Method 1 was followed using 4-chloro-3-nitrophenyl cyclopropyl ketone (1.0 eq), 3-(N-Boc-amino)piperidine (1.2 eq), and TEA (1.5 eq) at 55° C. for 48 hours yielding tert-butyl 1-(4-(cyclopropanecarbonyl)-2-nitrophenyl)piperidin-3-ylcarbamate (96%). LCMS (m/z): 390.1 (MH+); LC Rt=3.28 min.

WORKUP

后处理

  1. customat 55° C.
  2. customfor 48 hours