HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chloro-3-nitrophenyl cyclopropyl ketone → Tert-butyl 1-(4-(cyclopropanecarbonyl)-2-nitrophenyl)piperidin-3-ylcarbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chloro-3-nitrophenyl cyclopropyl ketone | HCID 1268259 | — |
| Reactant | 3-(Boc-amino)piperidine | HCID 4233041 | — |
| Product | Tert-butyl 1-(4-(cyclopropanecarbonyl)-2-nitrophenyl)piperidin-3-ylcarbamate | HCID 69043896 | 96% |
Reaction Steps
Method 1 was followed using 4-chloro-3-nitrophenyl cyclopropyl ketone (1.0 eq), 3-(N-Boc-amino)piperidine (1.2 eq), and TEA (1.5 eq) at 55° C. for 48 hours yielding tert-butyl 1-(4-(cyclopropanecarbonyl)-2-nitrophenyl)piperidin-3-ylcarbamate (96%). LCMS (m/z): 390.1 (MH+); LC Rt=3.28 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08822497B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-9a299b5b3ebe41029ca8be1e2e229ee6 |
| Source note | uspto-grants-2014_09 |