HCID 69046899, compound → Tert-butyl 1-(4-aminopyridin-3-yl)piperidin-3-ylcarbamate

HRID 69873Notes

Reaction equation

HRID 69873 reaction equation
[N+:1]([C:4]1[CH:9]=[CH:8][N:7]=[CH:6][C:5]=1[N:10]1[CH2:15][CH2:14][CH2:13][CH:12]([NH:16][C:17](=[O:23])[O:18][C:19]([CH3:22])([CH3:21])[CH3:20])[CH2:11]1)([O-])=O>C(O)C.C(OCC)(=O)C>[NH2:1][C:4]1[CH:9]=[CH:8][N:7]=[CH:6][C:5]=1[N:10]1[CH2:15][CH2:14][CH2:13][CH:12]([NH:16][C:17](=[O:23])[O:18][C:19]([CH3:21])([CH3:20])[CH3:22])[CH2:11]1

Participants

3

Reactant 1

HCID 69046899HCID 69046899, compound

Product 1

HCID 69095089Tert-butyl 1-(4-aminopyridin-3-yl)piperidin-3-ylcarbamateYield 79%

Reagents, catalysts & solvents 1

HCID 21584252Ethanol ethylacetateSolvent

Procedure

The method of Example 90 (Method 5) was followed using 1 eq of tert-butyl 1-(4-nitropyridin-3-yl)piperidin-3-ylcarbamate in 1:1 ethanol/ethyl acetate at 30 psi for 72 hours, yielding tert-butyl 1-(4-aminopyridin-3-yl)piperidin-3-ylcarbamate (79%). LCMS (m/z): 293.1 (MH+); LC Rt=2.14 min.

Workup

  1. customfor 72 hours

Sources & evidence

ORD record
ord-05f5aac40ac24acda8ecad55c1e45bf8
Source dataset
uspto-grants-2014_09
Patent number
US08822497B2

Reaction notes

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