Dichloromethane → 2-(3-Chloro-5-((4-(2-isopropylthiazole-4-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)methyl)phenyl)acetaldehyde

HRID 698759Notes

Reaction equation

HRID 698759 reaction equation
[Cl:1][c:2]1[cH:3][c:4]([CH2:5][N:6]2[CH2:7][CH2:8][C:9]3([CH2:10][N:11]([C:15](=[O:16])[c:17]4[n:18][c:19]([CH:22]([CH3:23])[CH3:24])[s:20][cH:21]4)[CH2:12][CH2:13][O:14]3)[CH2:25][CH2:26]2)[cH:27][c:28]([CH2:30][CH2:31][OH:32])[cH:29]1.[Cl:40][CH2:41][Cl:42].[OH:33][C:34]([C:35]([F:36])([F:37])[F:38])=[O:39]>>[Cl:1][c:2]1[cH:3][c:4]([CH2:5][N:6]2[CH2:7][CH2:8][C:9]3([CH2:10][N:11]([C:15](=[O:16])[c:17]4[n:18][c:19]([CH:22]([CH3:23])[CH3:24])[s:20][cH:21]4)[CH2:12][CH2:13][O:14]3)[CH2:25][CH2:26]2)[cH:27][c:28]([CH2:30][CH:31]=[O:32])[cH:29]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 57989350(9-(3-Chloro-5-(2-hydroxyethyl)benzyl)-1-oxa-4,9-diazaspiro[5.5]undecan-4-yl)(2-isopropylthiazol-4-yl)methanone

Product 1

HCID 579893542-(3-Chloro-5-((4-(2-isopropylthiazole-4-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)methyl)phenyl)acetaldehyde

Sources & evidence

ORD record
ord-2b8c2932105c490292f6add17aa55ae5
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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