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HRID69889

反应详情

EQUATION

反应方程式

HRID 69889 的结构方程式

REACTANTS

反应物

2
结构：Nc1ccc(Br)nc1C(=O)O
HCID45480452

3-Amino-6-bromopyridine-2-carboxylic acid

C6H5BrN2O2

结构：CC(C)(C)OC(=O)N[C@H]1CCCN(c2ccncc2N)C1
HCID59332360

tert-Butyl [(3S)-1-(3-aminopyridin-4-yl)piperidin-3-yl]carbamate

C15H24N4O2

PRODUCTS

生成物

1
结构：CC(C)(C)OC(=O)N[C@H]1CCCN(c2ccncc2NC(=O)c2nc(Br)ccc2N)C1
HCID86669187

未命名化合物

收率 45%

PROCEDURE

实验过程

Following method 11, (S)-tert-butyl 1-(3-aminopyridin-4-yl)piperidin-3-ylcarbamate was coupled to 3-amino-6-bromopicolinic acid and purified by SiO2 chromatography (EtOAc eluant) yielding (S)-tert-butyl 1-(3-(3-amino-6-bromopicolinamido)pyridin-4-yl)piperidin-3-ylcarbamate (45%). LCMS (m/z): 491.1 (MH+); LC Rt=2.89 min.

WORKUP

后处理

  1. custompurified by SiO2 chromatography (EtOAc eluant)