HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
3-Amino-6-bromopicolinic acid → (S)-tert-butyl 1-(3-(3-amino-6-bromopicolinamido)pyridin-4-yl)piperidin-3-ylcarbamate
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 3-Amino-6-bromopicolinic acid | HCID 45480452 | — |
| Edukt | (S)-tert-Butyl (1-(3-aminopyridin-4-yl)piperidin-3-yl)carbamate | HCID 59332360 | — |
| Produkt | (S)-tert-butyl 1-(3-(3-amino-6-bromopicolinamido)pyridin-4-yl)piperidin-3-ylcarbamate | HCID 86669187 | 45% |
Reaktionsschritte
Following method 11, (S)-tert-butyl 1-(3-aminopyridin-4-yl)piperidin-3-ylcarbamate was coupled to 3-amino-6-bromopicolinic acid and purified by SiO2 chromatography (EtOAc eluant) yielding (S)-tert-butyl 1-(3-(3-amino-6-bromopicolinamido)pyridin-4-yl)piperidin-3-ylcarbamate (45%). LCMS (m/z): 491.1 (MH+); LC Rt=2.89 min.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08822497B2 |
| Quelldatensatz | uspto-grants-2014_09 |
| ORD ID | ord-7df2abd8ae654f98a4ecd45d57abc34e |
| Quellennotiz | uspto-grants-2014_09 |