huagongshe.com
HRID69890

反应详情

EQUATION

反应方程式

HRID 69890 的结构方程式

REACTANTS

反应物

3
结构：CN1CCC(=O)CC1
HCID74049

1-Methyl-4-piperidone

C6H11NO

结构：CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+]
HCID5049666

Sodium triacetoxyborohydride

C6H10BNaO6

结构：Nc1ncc(Br)nc1C(=O)Nc1cnccc1N1CCCC(N)C1
HCID86669178

未命名化合物

PRODUCTS

生成物

1
结构：CN1CCC(NC2CCCN(c3ccncc3NC(=O)c3nc(Br)cnc3N)C2)CC1
HCID86669188

未命名化合物

收率 66%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：ClCCl
溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

To a solution of 3-amino-N-(4-(3-aminopiperidin-1-yl)pyridin-3-yl)-6-bromopyrazine-2-carboxamide in CH2Cl2 at room temperature was added 1-methylpiperidin-4-one (1.5 eq) followed by sodium triacetoxyborohydride (5.0 eq). The reaction was stirred at room temperature for 12 hours, concentrated, purified by reverse phase HPLC and lyophilized to provide 3-amino-6-bromo-N-(4-(3-(1-methylpiperidin-4-ylamino)piperidin-1-yl)pyridin-3-yl)pyrazine-2-carboxamide, (66%). LCMS (m/z): 489.2 (MH+).

WORKUP

后处理

  1. concentrationconcentrated
  2. custompurified by reverse phase HPLC