Water → 1,1-Dimethylethyl 4-[4-(3-amino-2-fluorophenyl)-5-(2-chloro-4-pyrimidinyl)-1,3-thiazol-2-yl]-4-methyl-1-piperidinecarboxylate

HRID 698903Notes

Reaction equation

HRID 698903 reaction equation
[CH2:41]([SnH:42]([CH2:43][CH2:44][CH2:45][CH3:46])[CH2:47][CH2:48][CH2:49][CH3:50])[CH2:51][CH2:52][CH3:53].[Cl:1][c:2]1[n:3][cH:4][cH:5][c:6](-[c:8]2[c:9](-[c:27]3[c:28]([F:40])[c:29]([NH:33][C:34]([O:35][CH2:36][CH:37]=[CH2:38])=[O:39])[cH:30][cH:31][cH:32]3)[n:10][c:11]([C:13]3([CH3:26])[CH2:14][CH2:15][N:16]([C:19](=[O:20])[O:21][C:22]([CH3:23])([CH3:24])[CH3:25])[CH2:17][CH2:18]3)[s:12]2)[n:7]1.[Cl:55][CH2:56][Cl:57].[OH2:54]>>[Cl:1][c:2]1[n:3][cH:4][cH:5][c:6](-[c:8]2[c:9](-[c:27]3[c:28]([F:40])[c:29]([NH2:33])[cH:30][cH:31][cH:32]3)[n:10][c:11]([C:13]3([CH3:26])[CH2:14][CH2:15][N:16]([C:19](=[O:20])[O:21][C:22]([CH3:23])([CH3:24])[CH3:25])[CH2:17][CH2:18]3)[s:12]2)[n:7]1

Participants

5

Reactant 4

HCID 962WaterHCID 5948TributylstannaneHCID 6344DichloromethaneHCID 579898811,1-Dimethylethyl 4-[5-(2-chloro-4-pyrimidinyl)-4-(2-fluoro-3-{[(2-propen-1-yloxy)carbonyl]amino}phenyl)-1,3-thiazol-2-yl]-4-methyl-1-piperidinecarboxylate

Product 1

HCID 579897231,1-Dimethylethyl 4-[4-(3-amino-2-fluorophenyl)-5-(2-chloro-4-pyrimidinyl)-1,3-thiazol-2-yl]-4-methyl-1-piperidinecarboxylate

Sources & evidence

ORD record
ord-c40ab8058aff45829375024cceab1f04
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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