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HRID69898

反应详情

EQUATION

反应方程式

HRID 69898 的结构方程式

REACTANTS

反应物

1
结构：CC(C)(C)OC(=O)N[C@@H]1CN(c2ccncc2[N+](=O)[O-])CC[C@H]1O[Si](C)(C)C(C)(C)C
HCID58386813

rel-1,1-Dimethylethyl N-[(3R,4R)-4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1-(3-nitro-4-pyridinyl)-3-piperidinyl]carbamate

C21H36N4O5Si

PRODUCTS

生成物

1
结构：CC(C)(C)OC(=O)N[C@@H]1CN(c2ccncc2N)CC[C@H]1O[Si](C)(C)C(C)(C)C
HCID58386806

未命名化合物

收率 99%

AUXILIARIES

试剂、催化剂与溶剂

2
结构：CCO
溶剂HCID702

Ethanol

C2H6O

结构：CCOC(C)=O
溶剂HCID8857

Ethyl acetate

C4H8O2

PROCEDURE

实验过程

Following Method 2 of Example 49, tert-butyl (3R,4R)-4-(tert-butyldimethylsilyloxy)-1-(3-nitropyridin-4-yl)piperidin-3-ylcarbamate in ethanol and ethyl acetate (1:1, 0.1 M solution) was reduced yielding tert-butyl (3R,4R)-1-(3-aminopyridin-4-yl)-4-(tert-butyldimethylsilyloxy)piperidin-3-ylcarbamate, (>99%). LCMS (m/z): 423.2 (MH+); LC Rt=3.78 min.