HuagongsheHuagongshe Chemistry Print Report · For research reference only
(+/-)-2-(4-Fluoro-1-(3-nitropyridin-4-yl)piperidin-3-yl)isoindoline-1,3-dione → HCID 69090590, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (+/-)-2-(4-Fluoro-1-(3-nitropyridin-4-yl)piperidin-3-yl)isoindoline-1,3-dione | HCID 77419824 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 69090590 | HCID 69090590 | 87% |
Reaction Steps
Following Method 2 of Example 49, (+/−)-2-(4-fluoro-1-(3-nitropyridin-4-yl)piperidin-3-yl)isoindoline-1,3-dione in ethanol and ethyl acetate (1:1, 0.1 M solution) was reduced yielding (+/−)-2-(1-(3-aminopyridin-4-yl)-4-fluoropiperidin-3-yl)isoindoline-1,3-dione, (87%). LCMS (m/z): 341.1 (MH+); LC Rt=2.23 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08822497B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-ed959042dfce45a48228793c4eab4849 |
| Source note | uspto-grants-2014_09 |