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HRID69905

反应详情

EQUATION

反应方程式

HRID 69905 的结构方程式

REACTANTS

反应物

1
结构：O=C1c2ccccc2C(=O)N1C1CN(c2ccncc2[N+](=O)[O-])CCC1F
HCID77419824

未命名化合物

PRODUCTS

生成物

1
结构：Nc1cnccc1N1CCC(F)C(N2C(=O)c3ccccc3C2=O)C1
HCID69090590

未命名化合物

收率 87%

AUXILIARIES

试剂、催化剂与溶剂

2
结构：CCO
溶剂HCID702

Ethanol

C2H6O

结构：CCOC(C)=O
溶剂HCID8857

Ethyl acetate

C4H8O2

PROCEDURE

实验过程

Following Method 2 of Example 49, (+/−)-2-(4-fluoro-1-(3-nitropyridin-4-yl)piperidin-3-yl)isoindoline-1,3-dione in ethanol and ethyl acetate (1:1, 0.1 M solution) was reduced yielding (+/−)-2-(1-(3-aminopyridin-4-yl)-4-fluoropiperidin-3-yl)isoindoline-1,3-dione, (87%). LCMS (m/z): 341.1 (MH+); LC Rt=2.23 min.