HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → (R)-1-(3-nitropyridin-4-yl)piperidin-3-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 4-Chloro-3-nitropyridine | HCID 2735781 | — |
| Reactant | 3-Hydroxypiperidine, (R)- | HCID 2759334 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | (R)-1-(3-nitropyridin-4-yl)piperidin-3-ol | HCID 69043765 | — |
Reaction Steps
Method 1 of Example 1 was followed using 1 equivalent each of 4-chloro-3-nitropyridine, (R)-3-hydroxypiperidine and triethylamine in DMF yielding (R)-1-(3-nitropyridin-4-yl)piperidin-3-ol, LCMS (m/z): 224.1 (MH+); LC Rt=1.06 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08822497B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-7fc92580cd7c43819eefdf4cfc5296c6 |
| Source note | uspto-grants-2014_09 |