huagongshe.com
HRID69914

反应详情

EQUATION

反应方程式

HRID 69914 的结构方程式

REACTANTS

反应物

3
结构：CCN(CC)CC
HCID8471

Triethylamine

C6H15N

结构：O=[N+]([O-])c1cnccc1Cl
HCID2735781

4-Chloro-3-nitropyridine

C5H3ClN2O2

结构：O[C@@H]1CCCNC1
HCID2759334

(3R)-3-Piperidinol

C5H11NO

PRODUCTS

生成物

1
结构：O=[N+]([O-])c1cnccc1N1CCC[C@@H](O)C1
HCID69043765

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CN(C)C=O
溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

Method 1 of Example 1 was followed using 1 equivalent each of 4-chloro-3-nitropyridine, (R)-3-hydroxypiperidine and triethylamine in DMF yielding (R)-1-(3-nitropyridin-4-yl)piperidin-3-ol, LCMS (m/z): 224.1 (MH+); LC Rt=1.06 min.