HuagongsheHuagongshe Chemistry Print Report · For research reference only
(+/-)-4-(3-(Tert-butyl dimethylsilyloxy)piperidin-1-yl)-3-nitropyridine → Tert-butyl (+/-)-4-(3-(tert-butyldimethylsilyloxy)piperidin-1-yl)pyridin-3-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (+/-)-4-(3-(Tert-butyl dimethylsilyloxy)piperidin-1-yl)-3-nitropyridine | HCID 69042279 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | Tert-butyl (+/-)-4-(3-(tert-butyldimethylsilyloxy)piperidin-1-yl)pyridin-3-amine | HCID 86669190 | — |
Reaction Steps
Following Method 2 of Example 49, (+/−)-4-(3-(tert-butyl dimethylsilyloxy)piperidin-1-yl)-3-nitropyridine in ethanol was reduced yielding tert-butyl (+/−)-4-(3-(tert-butyldimethylsilyloxy)piperidin-1-yl)pyridin-3-amine. LCMS (m/z): 308.2 (MH+); LC Rt=3.47 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08822497B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-5c17b6275585471488295f31a3912604 |
| Source note | uspto-grants-2014_09 |